Tielly Wang

Title: Assistant Professor
Department: Chemistry
Phone: 310-243-3388
Email: twang@csudh.edu
Office Location: NSM B304
Laboratory Location: NSM B339

Research Interests:

1. Identifying the potential protein targets for radio-chemotherapies.

Using proteomic technology to discover, characterize and develop assays for protein biomarkers for radioresistant breast cancer cells of different ethnicity such as Hispanic, Asian, African American and Caucasian. Despite the knowledge that ethnicity matters in breast cancer, most studies of breast cancer radio-chemo resistance have not been designed to yield results that apply to different ethnic groups.

2.Elucidating the mechanisms of the cellular radiation and drug resistance.

Studying the role that PrxII plays in cell function of radioresistant tumor by limiting oxidative stress directly via antioxidant effects and indirectly by protein-protein interactions to modulate signaling involved in cell proliferation and cell death.

Highest degree obtained: Ph.D.

Discipline: Biochemistry and Biophysics

Institution/Year: State University of New York @ Stony Brook/1999

Thesis Title/Director: The mechanistic aspect of PLC in G protein signal transduction pathway

Master's Degree:

Discipline: Chemistry

Institution/Year: Iowa State University/1995

Thesis Title/Director: The crystal and molecular structure of Azatranes/Robert A. Jacobson

Bachelor's Degree:

Discipline: Chemistry

Institution/Year: Jilin University/1987

Thesis Title/Director: Synthesis of molecular sieve from Suzhou soil

Positions since highest degree earned:

Assistant Professor, California State university, 9/05 - present

Beckman Fellow, Beckman Research Institute of the City of Hope, 6/01 – 8/05

Grants:

Beckman Fellowship: 2001

RSCAAP award: 2007

Awards & Recognitions:

1999: Excellent in Research Award, State University of New York at Stony Brook
2001: Invited talk: 92nd American Association for Cancer Research, New Orleans
2001: Beckman Fellowship Award, Beckman Research Institute of the City of Hope, Duarte
2004: Invited talk: RSO annual meeting of Beckman Research Institute of the City of Hope,
2004: Invited talk: Beckman fellow symposium at Institute of California Technology
2005: Invited talk: College of Life Science and College of Chemistry, Jilin University
2007: Invited talk: Cell & Molecular Biology Graduate Program, Colorado State University

Publications:

1. Shao, J., Zhou, B., Di Bilio, AJ., Zhu, LJ., Wang, T., Qi, C., Shih, J., Yen, Y. (2006) A Ferrous-triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase. Mol Cancer Ther. 5:586-92

2. Xue, L., Zhou, B., Liu, X., Wang, T., Shih, J., Qi, C., Yen, Y. (2006) Structurally dependent redox property of ribonucleotide reductase subunit p53R2. Cancer Research, 66 (4): 1900-1905.

3. Wang, T*., Tamae, D., Shiverly, J.E., Lee, T. and Li, J. J. (2005) The role of Prx II in radioresistant MCF-7 breast cancer cells. Cancer Research, 65(22):10338-46.

4. Wang, T., Hu, YC.,Tamae, D., Ozeki, M., Gao, Q., Gius, D., and Li, JJ. (2005) Co-activation of NFB and Erk in protection cells from radiation toxicity. J Biol Chem., Vol. 280, Issue 13, 12593-12601.

5. Wang, T., Guo, G., Wong, J., and Li, JJ. (2004) Expression of ErbB2 enhances radiation induced NFB activation. Oncogene. 23, 535-545.

6. Guo, G, Yan-Sanders, Y., Lyn-Cook, B. D, Wang, T., Tamae, D., and Li, JJ. (2003) NFB mediated manganese superoxide dismutase in radiation induced adaptive responses. Mol. Cell. Biol., 23, 2362-2378.

7. Wang, T., and Li, J. J. (2002) NFB activation and cell adaptive response. Int. J. Immunopharm., 2(11), 1509-1618.

8. Wang, T., Arifoglu,P., Ronai,Z., and Tew, KD. (2001) Probing the interaction between Glutathione S-Transferase P1-1 and c-Jun NH2 Terminal Kinase. J. Biol. Chem., 276(24): 20999-21003.

9. Ruscoe, JE., Rosario, LA., Wang, T., Gaté L., Arifoglu P., Wolf, CR, Henderson, CJ, Ronai, Z., and Tew, KD. (2001) Pharmacological or genetic manipulation of glutathione s-transferase p1-1 (GST) influences cell proliferation pathways. J. Pharmacol. Exp. Ther. 298(1): 339-345.

10. Wang, T., Dowal L., El-Maghrabi, R., Rebecchi, M and Scarlata, S. (2000) The Pleckstrin homology domain of phospholipase C -  links the binding of G to activation of the catalytic core. J. Biol. Chem., 275(11), 7466-7469.

 
Presentations:

Wang, T*., Tamae, D., Shiverly, J.E., Lee, T. and Li, J. J. (2005) The role of Prx II in radioresistant MCF-7 breast cancer cells. Gordon Research Conference.

Wang, T., Hu, YC.,Tamae, D., Ozeki, M., Gao, Q., Gius, D., and Li, JJ. (2004) Co-activation of NFB and Erk in protection cells from radiation toxicity. American Association for Cancer Research annual meeting.

Wang, T., Guo, G., Wong, J., and Li, JJ. (2003) Expression of ErbB2 enhances radiation induced NFB activation. Radiation Research Society annual meeting.

Wang, T., Arifoglu,P., Ronai,Z., and Tew, KD. (2001) Probing the interaction between Glutathione S-Transferase P1-1 and c-Jun NH2 Terminal Kinase. American Association for Cancer Research annual meeting.

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Last updated September 12, 2007 by mk